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Munguva ichangopfuura, imwe nyaya yepepanhau reGunma University School of Medicine muJapan yakashuma kuti chimwe chipatara chakakonzera cyanosis muvana vachangoberekwa vanoverengeka nemhaka yokusvibiswa kwemvura yemupombi. Ongororo iyi inoratidza kuti kunyangwe mvura yakasefa inogona kusvibiswa nekusaziva uye kuti vacheche vanowanzoita methemoglobinemia.

Methemoglobinemia Kubuda muNeonatal ICU uye Maternity Wadhi

Vana gumi vachangozvarwa mukamuri inochengeterwa vacheche uye muwadhi yevanosunungukira vakagadzira methemoglobinemia nekuda kwekudyiswa mukaka wakagadzirwa nemvura yemupombi ine utachiona. Methemoglobin concentrations kubva pa9.9% kusvika 43.3%. Varwere vatatu vakagamuchira methylene yebhuruu (museve), iyo inodzorera simba rekutakura okisijeni yehemoglobin, uye mushure memaawa mapfumbamwe, varwere vese gumi vakadzokera kune zvakajairika paavhareji. Mufananidzo B unoratidza mufananidzo wevhavha yakakuvadzwa uye basa rayo rinowanzoita. Mufananidzo C unoratidza hukama pakati pemvura yekunwa uye pombi yekudziya yekutenderera. Mvura yekunwa yechipatara inobva mutsime uye inopinda nemuchina wekuchenesa uye sefa inouraya mabhakitiriya. Mutsara wekutenderera wekupisa unoparadzaniswa kubva pamvura yekunwa nevhavha yekuongorora. Kukundikana kwevhavhavha yecheki kunokonzera kuti mvura iyerere ichidzoka kubva mumutsara wekutenderera wekupisa ichienda mumutsetse wemvura yekunwa.

Kuongororwa kwemvura yemupombi kwakaratidza yakakwira nitrite. Mushure mekuongorora kwakawedzerwa, takaona kuti mvura yekunwa yakasvibiswa nekuda kwekukundikana kwevhavha yakakonzerwa nekudzokera shure kwechipatara chekupisa. Mvura iri mumhepo yekudziya ine zvigadziriso (Figure 1B uye 1C). Kunyange zvazvo mvura yemupombi inoshandiswa mukugadzirwa kwefodya yevacheche yakacheneswa nemasefa kuti isangane nemitemo yenyika, mafirita haakwanisi kubvisa nitrites. Kutaura idi, mvura yemupombi muchipatara chose yakanga ine utachiona, asi hapana nomumwe wavarwere vakura akava nemethemoglobin.

Zvichienzaniswa nevana vakura nevakuru, vacheche vari pasi pemwedzi miviri vane mukana wekuita methemoglobinosis nekuti vacheche vanonwa mvura yakawanda pakirogiramu yehuremu hwemuviri uye vane basa rakaderera reNADH cytochrome b5 reductase, inoshandura methemoglobin kuita hemoglobin. Mukuwedzera, iyo pH yakakwirira mudumbu remucheche inobatsira kuvapo kwebhakitiriya inoderedza nitrate muchikamu chepamusoro chekudya, chinoshandura nitrate kuita nitrite.

Mhosva iyi inoratidza kuti kunyangwe mukaka wakagadzirwa uchishandiswa mvura yakacheneswa zvakanaka, methemoglobin inogona kukonzerwa nekusvibiswa kwemvura kusingaite. Mukuwedzera, nyaya iyi inosimbisa chokwadi chokuti vacheche vanobatwa nemethemoglobin kupfuura vanhu vakuru. Kuziva zvinhu izvi kwakakosha pakuziva kwakabva methemoglobin uye kudzikisira huwandu hwekubuda kwayo.