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Interferon chiratidzo chakavanzwa nehutachiona muvazukuru vemuviri kuita kuti immune system iite, uye mutsara wekudzivirira kubva kuhutachiona.Type I interferons (zvakadai sealpha nebeta) zvakadzidzwa kwemakumi emakore semishonga inorwisa mavhairasi.Zvisinei, mhando yeI interferon receptors inoratidzwa mumatishu akawanda, saka hutungamiri hwemhando yeI interferon huri nyore kutungamirira kuhuwandu hwekuzvidzivirira kwemuviri, zvichikonzera mutsara wemigumisiro.Musiyano ndewekuti mhando III interferon (λ) receptors inongoratidzwa mu epithelial tishu uye mamwe maseru edziviriro, semapapu, turakiti rekufema, ura, uye chiropa, uko iyo novel coronavirus inobata, saka interferon λ ine mashoma mhedzisiro.PEG-λ inogadziriswa ne polyethylene glycol pamusana pe interferon yakasikwa λ, uye nguva yekutenderera kwayo muropa yakareba zvikuru kupfuura ye interferon yakasikwa.Ongororo dzinoverengeka dzakaratidza kuti PEG-λ ine yakafara-spectrum antiviral chiitiko

Kubva muna Kubvumbi 2020, masayendisiti kubva kuNational Cancer Institute (NCI) muUnited States, King's College London kuUnited Kingdom nemamwe masangano ekutsvagisa akaburitsa zvakataurwa muJ Exp Med achikurudzira zvidzidzo zvekiriniki vachishandisa interferon λ kurapa Covid-19.Raymond T. Chung, director weHepatobiliary Center paMassachusetts General Hospital muUnited States, akazivisawo muna Chivabvu kuti ongororo yekiriniki yakatangwa nemuongorori ichaitwa kuongorora kushanda kwePEG-λ kurwisa Covid-19.

Zviyero zviviri zvechikamu chechipiri chekiriniki zvakaratidza kuti PEG-λ inogona kuderedza zvakanyanya huwandu hwehutachiona muvarwere vane COVID-19 [5,6].Musi waKukadzi 9, 2023, iyo New England Journal yeMishonga (NEJM) yakaburitsa mhedzisiro yechikamu chechitatu chinogadziriswa chepuratifomu chiyedzo chinodaidzwa kuti TOGETHER, inotungamirwa nenyanzvi dzeBrazil neCanada, iyo yakawedzera kuongorora kurapa kwePEG-λ pavarwere veCOVID-19. [7].

Varwere vaiuya neacute Covid-19 zviratidzo uye vachiuya mukati memazuva manomwe ekutanga kwechiratidzo vakagamuchira PEG-λ (rimwechete subcutaneous jekiseni, 180 μg) kana placebo (jekiseni rimwechete kana remuromo).Mhedzisiro yekutanga yemubatanidzwa yaive yekuchipatara (kana kuendeswa kuchipatara chepamusoro) kana kushanya kwedhipatimendi rekukurumidzira kuCovid-19 mukati memazuva makumi maviri nemasere ekuita randomisation (kutarisa> maawa matanhatu).

Iyo novel coronavirus yanga ichichinja kubva pakatanga kubuda.Naizvozvo, zvinonyanya kukosha kuona kana PEG-λ ine kurapa mhedzisiro pane akasiyana novel coronavirus akasiyana.Chikwata chakaita ongororo yeboka remhando dzakasiyana dzehutachiona hwakatapurira varwere muyedzo iyi, kusanganisira Omicron, Delta, Alpha, uye Gamma.Mhedzisiro yacho yakaratidza kuti PEG-λ yaive inoshanda muvarwere vese vakatapukirwa nemhando idzi, uye inonyanya kushanda muvarwere vane Omicron.

Panyaya yehutachiwana hwehutachiwana, PEG-λ yakanga ine hutano hunokosha hwekurapa kune varwere vane hutachiwana hwepamusoro hwehutachiwana, asi pasina kurapa kwakakosha kwakaonekwa kune varwere vane hutachiwana hwehutachiona hwehutachiona.Kushanda uku kwakada kuenzana nePfizer's Paxlovid (Nematovir/Ritonavir).

Zvinofanira kuonekwa kuti Paxlovid inobatwa nemuromo nemapiritsi matatu kaviri pazuva kwemazuva mashanu.PEG-λ, kune rumwe rutivi, inongoda jekiseni rimwechete re subcutaneous kuti riwane kushanda kwakafanana nePaxlovid, saka ine kutevedzera zviri nani.Pamusoro pekuteerera, PEG-λ ine zvimwe zvakanakira pamusoro pePaxlovid.Zvidzidzo zvakaratidza kuti Paxlovid iri nyore kukonzera kusangana kwezvinodhaka uye kukanganisa metabolism yemamwe madhiragi.Vanhu vane huwandu hwakanyanya hweCovid-19, sevarwere vakura nevarwere vane zvirwere zvisingaperi, vanowanzotora mishonga kwenguva yakareba, saka njodzi yePaxlovid mumapoka aya yakanyanya kudarika PEG-λ.

Mukuwedzera, Paxlovid inhibitor inotarisa hutachiona hweproteases.Kana iyo viral protease ikachinja, mushonga unogona kusashanda.PEG-λ inokwidziridza kubviswa kwehutachiona kuburikidza nekuita kusadzivirirwa kwemuviri wega, uye haina kunanga chero hutachiona.Nokudaro, kunyange kana hutachiona huchichinja mberi mune ramangwana, PEG-λ inotarisirwa kuchengetedza kushanda kwayo.

Nekudaro, iyo FDA yakati haizobvumidza kushandiswa kwekukurumidzira kwePEG-λ, zvakanyanya kuodza mwoyo masayendisiti akabatanidzwa muchidzidzo.Eiger anoti izvi zvinogona kunge zviri nekuda kwekuti chidzidzo chacho hachina kusanganisa nzvimbo yekuyedza yekiriniki yeUS, uye nekuti kuyedza kwakatangwa uye kwakaitwa nevaongorori, kwete makambani emishonga.Nekuda kweizvozvo, PEG-λ ichada kuisa mari yakawanda uye nguva yakawanda isati yatangwa muUnited States.

Semushonga wakafararira antiviral, PEG-λ haingonangi iyo novel coronavirus, inogona zvakare kuwedzera kubvumidzwa kwemuviri kune zvimwe zvirwere zvehutachiona.PEG-λ ine zvinogona kuitika pahutachiona hwefuruwenza, kufema syncytial virus uye mamwe makoronavirus.Zvimwe zvidzidzo zvakaratidzawo kuti λ interferon mishonga, kana yakashandiswa kare, inogona kumisa utachiona kubva pakukanganisa muviri.Eleanor Fish, nyanzvi yokudzivirira zvirwere paYunivhesiti yeToronto muCanada uyo akanga asina kubatanidzwa mukuongorora kwaTOGETHER, akati: “Kushandiswa kukuru kworudzi urwu rweinterferon kwaizova kudzivirira, zvikurukuru kudzivirira vanhu vari mungozi huru pautachiona mukati mokuputika.”