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Parizvino, magnetic resonance imaging (MRI) iri kusimukira kubva kumagariro echinyakare imaging uye kushanda kwekufungidzira kuenda ku molecular imaging. Multi-nuclear MR Inogona kuwana ruzivo rwakasiyana-siyana rwemetabolite mumuviri wemunhu, ichichengetedza kugadziriswa kwenzvimbo, kuvandudza hutsananguro hwekuonekwa kwehutano hwehupenyu uye hwehutachiona hwehutachiona, uye ikozvino ndiyo chete teknolojia inogona kusava-invasive quantitative analysis of human dynamic molecular metabolism in vivo.

Nekudzika kweakawanda-musimboti MR Tsvagiridzo, ine yakafara tarisiro yekushandisa mukutanga kutariswa uye kuongororwa kwemamota, chirwere chemoyo, neurodegenerative chirwere, endocrine system, digestive system uye chirwere chekufema system, uye nekukurumidza kuongororwa kwemaitiro ekurapa. Philips 'yazvino yakawanda-yakakosha yekiriniki yekutsvagisa chikuva ichabatsira kufungidzira uye vanachiremba vekiriniki kuita yekucheka-kumucheto kukiriniki yekutsvagisa. Dr. Sun Peng naDr. Wang Jiazheng vanobva kuPhilips Clinical and Technical Support Department vakapa sumo yakadzama yekuvandudzwa kwe-multi-NMR uye nzira yekutsvaga yePhilips 'itsva yakawanda yeMR Platform.

Magnetic resonance yakahwina Mubairo weNobel kashanu munhoroondo yayo, munzvimbo dzese dzefizikisi, chemistry, biology, uye mushonga, uye yakawana budiriro huru mumisimboti yefizikisi, organic molecular chimiro, biological macromolecular chimiro dynamics, uye kiriniki yekufungidzira yekurapa. Pakati pavo, magnetic resonance imaging yave imwe yeanonyanya kukosha yekiriniki yekurapa imaging technologies, inoshandiswa zvakanyanya mukuongororwa kwezvirwere zvakasiyana-siyana munzvimbo dzakasiyana dzemuviri wemunhu. Nekuenderera mberi kwekuvandudzwa kwezvido zvehutano, kudiwa kukuru kwekukurumidza kuongororwa uye kukurumidza kukurumidza kuongororwa kuri kusimudzira kuvandudzwa kwemagineti resonance imaging kubva kumagariro echinyakare imaging (T1w, T2w, PDw, nezvimwewo), inoshanda imaging (DWI, PWI, etc.) kune molecular imaging (1H MRS Uye akawanda-core MRS/MRI).

Iyo yakaoma yekumashure ye1H yakavakirwa MR Tekinoroji, inopindirana spectra, uye mvura/mafuta compression inodzikamisa nzvimbo yayo seye molecular imaging tekinoroji. Chete nhamba shoma yemamorekuru (choline, creatine, NAA, nezvimwewo) inogona kuonekwa, uye zvakaoma kuwana dynamic molecular metabolic process. Kubva pamhando dzakasiyana-siyana dzenyukiredhi (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR Inogona kuwana ruzivo rwakasiyana-siyana rwemetabolite yemuviri wemunhu, nehupamhi hwepamusoro uye hutsananguro hwepamusoro, uye parizvino ndiyo yega isiri-invasive, inogadzika yeredhiyo inoparadza (stable metabolite) (glucose, amino acids, fatty acids - isiri-chepfu) yehuwandu hwekuongorora kwevanhu vane simba rema molecular metabolic maitiro.

Nekuenderera mberi kwekubudirira mune magnetic resonance hardware system, kukurumidza kutevedzana nzira (Multi-Band, Spiral) uye acceleration algorithm (compressed sensing, deep learning), multi-core MR Imaging / spectroscopy inokura zvishoma nezvishoma: (1) inotarisirwa kuva chinhu chinokosha chekucheka-kumucheto molecular biology, biochemistry uye tsvakurudzo yemetabolism yevanhu; (2) Sezvainofamba kubva pakutsvakurudza kwesayenzi kuenda kuchipatara chekudzidzira (nhamba yemakiriniki ekuedzwa kwakavakirwa pa-multi-core MR Ari kuenderera mberi, FIG. 1), ine tarisiro yakafara mukutanga kuongororwa uye kuongororwa kwekenza, yemwoyo, neurodegenerative, digestive uye zvirwere zvekufema, uye kukurumidza kuongorora kushanda.

Nekuda kweiyo yakaoma misimboti yemuviri uye yakakwirira tekinoroji kuoma kweMR Munda, akawanda-musimboti MR Yakave yakasarudzika nzvimbo yekutsvagisa yeashoma epamusoro einjiniya ekutsvagisa masangano. Kunyange zvazvo multicore MR Yaita kufambira mberi kwakakosha mushure memakumi emakore ebudiriro, kuchine kushaikwa kwe data yekiriniki yakakwana yekufambisira mberi iyi ndima kuti ishumire varwere zvechokwadi.

Zvichienderana nekuenderera mberi kwekuvandudza mumunda weMR, Philips akazotyora bhodhoro rekusimudzira reMR yakawanda uye akaburitsa chikuva chitsva chekiriniki yekutsvagisa ine nuclides yakawanda muindastiri. Iyi puratifomu ndiyo yega-yakawanda-yakakosha sisitimu munyika yekugamuchira EU Safety Conformity Certification (CE) uye US Chikafu neDrug Administration (FDA) chitupa, ichigonesa chigadzirwa-level yakazara-stack yakawanda-yakakosha MR Solution: FDA-yakatenderwa makoiri, yakazara kutevedzana kufukidzwa, uye opareta chiteshi kuvaka patsva. Vashandisi havadi kuve vakashongedzerwa nehunyanzvi magineti resonance fizikisi, mainjiniya ekodhi uye vagadziri veRF gradient, zviri nyore pane zvechinyakare 1H spectroscopy/ imaging. Kukwidziridza kudzikiswa kweakawanda-musimboti MR Operating mutengo, yemahara switch pakati pekutsvagisa kwesainzi uye nzira yekiriniki, iyo inokurumidza kudzoreredza mutengo, kuitira kuti akawanda-musimboti MR Chokwadi mukiriniki.

Multi-core MR Ndiyo nzira yakakosha ye "14th Makore mashanu Medical Equipment Indasitiri Development Plan", uye ndiyo yakakosha tekinoroji yekufungidzira kwekurapa kutyora muitiro uye kusanganisa nekucheka-kumucheto biomedicine. Philips China masayendisiti timu, inotungamirwa nekuvandudza vatengi 'sainzi yekutsvagisa uye kugona hunyanzvi, yakaita tsvakiridzo yakarongeka pane akawanda-musimboti MR. Dr. Sun Peng, Dr. Wang Jiazheng et al. akatanga akurudzira pfungwa yeMR-nucleomics muNMR muBiomedicine (yepamusoro Journal of the First Region of Spectroscopy yeChinese Academy of Sciences), iyo inogona kushandisa MR Kubva pane zvakasiyana nuclides kuona zvakasiyana-siyana zvemasero uye pathological maitiro. Nokudaro, kutonga kwakakwana uye kuongororwa kwechirwere uye kurapwa kunogona kuitwa [1]. Pfungwa yeMR Multinucleomics ichave kutungamira kweramangwana reMR Development. Iri pepa ndiyo yekutanga kuongororwa kwakarongeka kwe-multi-core MR Munyika, inovhara nheyo yezvinyorwa zve-multi-core MR, pre-clinical research, kliniki shanduko, hardware development, algorithm progress, engineering practice nezvimwe zvinhu (Mufananidzo 2). Panguva imwecheteyo, boka revasayendisiti rakabatana naProfessor Song Bin weWest China Hospital kuti vapedze chinyorwa chekutanga chekuongorora nezve shanduko yekiriniki ye-multi-core MR MuChina, iyo yakabudiswa mumagazini Insights into Imaging [2]. Kuburitswa kweakateedzana zvinyorwa pamulticore MR Zvinoratidza kuti Philips inonyatso kuunza muganho wemulticore molecular imaging kuChina, kune vatengi veChinese, uye kuvarwere veChinese. Mukuwirirana nepfungwa huru ye "muChina, yeChina", Philips achashandisa multi-core MR Kukurudzira kukurudzirwa kweChina magnetic resonance uye kubatsira chikonzero cheChina chine utano.

Multi-nuclear MRI ndiyo tekinoroji iri kubuda. Nekuvandudzwa kweMR Software uye hardware, yakawanda-nuclear MRI yakashandiswa kune yekutanga uye yekiriniki yekushandura tsvakurudzo yehurongwa hwevanhu. Yayo yakasarudzika mukana ndeyekuti inogona kuratidza chaiyo-nguva inosimba metabolic maitiro mune akasiyana pathological maitiro, nekudaro ichipa mikana yekukurumidza kuongororwa kwezvirwere, kuongororwa kwekuita, kuita sarudzo yekurapa uye kukura kwezvinodhaka. Inogona kutobatsira kuongorora nzira itsva dzepathogenesis.

Kuti usimudzire kufambira mberi kwendima iyi, kushingaira kubatanidzwa kwenyanzvi dzekiriniki kunodiwa. Kuvandudzwa kwekiriniki yemapuratifomu akawanda kwakakosha, kusanganisira kuvakwa kweakakosha masisitimu, kumisikidzwa kwetekinoroji, kuwanda uye kumisikidzwa kwemhedzisiro, kuongororwa kwemaprobes matsva, kubatanidzwa kweruzivo rwakawanda rwemetabolism, nezvimwewo, mukuwedzera mukuvandudzwa kwemiedzo yakawanda inotarisirwa, kuitira kusimudzira shanduko yekiriniki ye advanced multicore MR Technology. Isu tinotenda zvakasimba kuti multi-core MR Ichapa nhanho yakafara yekufungidzira uye nyanzvi dzekiriniki kuita tsvakiridzo yekiriniki, uye mhedzisiro yayo ichabatsira varwere pasi rese.